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(15) In a separate animal study by Mieczkowska et al., a comparison of liraglutide to dapagliflozin on bone strength and microarchitecture in insulin-resistant and obese mice found no indication of improved bone strength or microarchitecture by either substance

This may relate in part to myocardial benefits, as noted above, or potentially improvements in skeletal muscle function and peripheral oxygen uptake, which are more dramatically impaired in patients with HFpEF and more severe inflammation 35

The analysis notes TikTok updated its Community Guidelines in line with the new ownership before the first phase of the study